Best Necrobinder build in Slay the Spire 2: Best cards, strategy, and more

The Necrobinder is one of the two new characters in Slay the Spire 2, and it's a slightly tricky character to manage. Unlike the other four choices, the Necrobinder doesn't fight alone. She has her loyal minion in the form of Osty. To win more fights, you'll have to strengthen the minion efficiently. Let's look at how to master the angel of death to clear all available acts.Table of contentsHow to use Necrobinder in Slay the Spire 2Best Necrobinder deck in Slay the Spire 2Best relics for Necrobinder in Slay the Spire 2How to use Necrobinder in Slay the Spire 2 The Necrobinder is a spellcaster who can use death and abilities around it to defeat enemies. However, she's not alone, as she's well supported by Osty. Her companion can do and take damage, and often works as a shield for her. Screenshot by Destructoid However, she is also arguably the most difficult character to manage. She has the lowest health pool among all available choices. Her deck also requires a lot of synergy between the cards to bring the best out of her. With Necrobinder, you'll have to be patient to set up the combos before you can go on the offensive.Best Necrobinder deck in Slay the Spire 2 There are two approaches to take with Necrobinder. One route is to use the Doom mechanic. While I am yet to get consistent success with Doom, utilizing Osty is the way to go. It's easier to set up your companion to do massive damage once you've got a key piece in play. The core strategy is simple: you build up Otsy while thinning down Necrobinder's options. Once Otsy has enough HP, he will act as your shield (and also your damage dealer). Screenshot by Destructoid Early commons and uncommonsCardReasonProtectorFor 1 Energy, Osty does 10 damage. If you have increased Osty's HP, it will increase the damage by the same amount. SnapFor 1 Energy, you get to do 7 damage and also retain a card to play next turn. High FiveYou get to do 11 damage to all enemies, and also apply Vulnerable for them. For 2 Energy, that's a great outcome. RattleThis card allows Osty to do 7 damage and land multiple hits based on how many times he has attacked in a turn. Best cardsCardReasonFetchThe card costs 0 Energy while allowing Osty to do 3 damage and draw a card. Allows you to trigger cards like Flatten for 0 Energy.FlattenOnce you manage to land a singular attack with Osty in a turn, this card can be used to 12 damage for free. ReanimateYou can spend 3 Energy to grow Osty by 20. Sic 'EmYou spend 1 Energy to do 5 damage, but Osty will also grow by 2 every time he attacks in a turn. SpurFor 1 Energy, you get to grow Osty by 3 and heal him further by 5. Best relics for Necrobinder in Slay the Spire 2 Necrobinder doesn't require any specific relic as such to shine. With Otsy, you can go with almost any relic, but look out for the Bone Flute. The Bone Flute allows her to gain 2 Block whenever Otsy does damage. The additional shield can always prove to be useful. The post Best Necrobinder build in Slay the Spire 2: Best cards, strategy, and more appeared first on Destructoid.

Mar 8, 2026 - 17:33

Best Necrobinder build in Slay the Spire 2: Best cards, strategy, and more

The Necrobinder is one of the two new characters in Slay the Spire 2, and it's a slightly tricky character to manage.

Unlike the other four choices, the Necrobinder doesn't fight alone. She has her loyal minion in the form of Osty. To win more fights, you'll have to strengthen the minion efficiently. Let's look at how to master the angel of death to clear all available acts.

Table of contents

How to use Necrobinder in Slay the Spire 2

The Necrobinder is a spellcaster who can use death and abilities around it to defeat enemies. However, she's not alone, as she's well supported by Osty. Her companion can do and take damage, and often works as a shield for her.

Screenshot by Destructoid However, she is also arguably the most difficult character to manage. She has the lowest health pool among all available choices. Her deck also requires a lot of synergy between the cards to bring the best out of her. With Necrobinder, you'll have to be patient to set up the combos before you can go on the offensive.

Best Necrobinder deck in Slay the Spire 2

There are two approaches to take with Necrobinder. One route is to use the Doom mechanic. While I am yet to get consistent success with Doom, utilizing Osty is the way to go. It's easier to set up your companion to do massive damage once you've got a key piece in play.

The core strategy is simple: you build up Otsy while thinning down Necrobinder's options. Once Otsy has enough HP, he will act as your shield (and also your damage dealer).

Screenshot by Destructoid Early commons and uncommons

Card

Reason

Protector

For 1 Energy, Osty does 10 damage. If you have increased Osty's HP, it will increase the damage by the same amount.

Snap

For 1 Energy, you get to do 7 damage and also retain a card to play next turn.

High Five

You get to do 11 damage to all enemies, and also apply Vulnerable for them. For 2 Energy, that's a great outcome.

Rattle

This card allows Osty to do 7 damage and land multiple hits based on how many times he has attacked in a turn.

Best cards

Card

Reason

Fetch

The card costs 0 Energy while allowing Osty to do 3 damage and draw a card. Allows you to trigger cards like Flatten for 0 Energy.

Flatten

Once you manage to land a singular attack with Osty in a turn, this card can be used to 12 damage for free.

Reanimate

You can spend 3 Energy to grow Osty by 20.

Sic 'Em

You spend 1 Energy to do 5 damage, but Osty will also grow by 2 every time he attacks in a turn.

Spur

For 1 Energy, you get to grow Osty by 3 and heal him further by 5.

Best relics for Necrobinder in Slay the Spire 2

Necrobinder doesn't require any specific relic as such to shine. With Otsy, you can go with almost any relic, but look out for the Bone Flute. The Bone Flute allows her to gain 2 Block whenever Otsy does damage. The additional shield can always prove to be useful.

The post Best Necrobinder build in Slay the Spire 2: Best cards, strategy, and more appeared first on Destructoid.

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