All Acts and Areas in Mewgenics and how to unlock them

The main campaign of Mewgenics is spread across different regions, and most of them remain locked at first. However, you'll be able to unlock these regions by playing the game. Unlocking most of the areas is a simple task. You have to unlock the previous one to move on to the next location. However, some, like the Secret Domains, are tricky to discover. The requirements for unlocking those regions tend to be tricky. How to unlock all Areas and Acts in Mewgenics Everyone begins playing at The Alley. The Alley is the first location of Mewgenics, and it comes unlocked by default. It's going to be the very first mission that you complete as part of your adventure. AreaHow to UnlockThe AlleyAs the first area of the game, The Alley is unlocked by default. The SewersFinish a run in The Alley.The CavesFinish a run in The Sewers. This is the third location you'll access. The JunkyardComplete The Alley's hard branch, which is tougher than the default option. The BoneyardFinish a run in The Junkyard. The Throbbing DomainThis is going to be the first secret area that you can unlock. Once you complete Guillotina's first boss fight, take the Throbbing Gristle to the Wall of Flesh. Then, take the Putrid Leach from Guillotina's second boss fight to the Throbbing Artery in The Boneyard. Complete the third boss fight, and equip her head to one of your cats. Then, go to the altar in the Throbbing Domain and sacrifice the cat (that has Guillotina's head equipped). DesertFinish a run in The Boneyard and in The Caves. The BunkerFinish a run in The Desert. The CoreFinish a run in The Bunker. The CraterFinish a run in The Desert. The MoonFinish a run in The Crater. The RiftThis is the second secret stage in the game. You'll meet Pyrophina and Zaratan once you've cleared runs on The Moon and The Core. Defeat both of them and take the Burning orb from Pyrophina. Feed it to the Man on the Moon by making a cat stand in front of him while holding the item. Next, charge Zaratana's Shard by killing 20 enemies with the item equipped. Take the shard to the Coven on the Core and insta-kilit with the Shard. Now, both Pyrophina and Zaratana will return to your house. Once their fight is over, you'll get a collar. If you get Pyrophina's collar, take it to the obelisk at the end of The Moon. If you get Zaratana's collar, take it to the Core obelisk. The LabFinish a run in The Core and The Moon. Ice AgeFinish a run in The Lab.The FutureFinish a run in The Lab.The JurassicFinish a run in The Ice Age. The EndFinish a run in The Future. The InfiniteFinish a run in The Jurassic and The End. The post All Acts and Areas in Mewgenics and how to unlock them appeared first on Destructoid.

Feb 17, 2026 - 06:22

All Acts and Areas in Mewgenics and how to unlock them

The main campaign of Mewgenics is spread across different regions, and most of them remain locked at first. However, you'll be able to unlock these regions by playing the game.

Unlocking most of the areas is a simple task. You have to unlock the previous one to move on to the next location. However, some, like the Secret Domains, are tricky to discover. The requirements for unlocking those regions tend to be tricky.

How to unlock all Areas and Acts in Mewgenics

Everyone begins playing at The Alley. The Alley is the first location of Mewgenics, and it comes unlocked by default. It's going to be the very first mission that you complete as part of your adventure.

Area

How to Unlock

The Alley

As the first area of the game, The Alley is unlocked by default.

The Sewers

Finish a run in The Alley.

The Caves

Finish a run in The Sewers. This is the third location you'll access.

The Junkyard

Complete The Alley's hard branch, which is tougher than the default option.

The Boneyard

Finish a run in The Junkyard.

The Throbbing Domain

This is going to be the first secret area that you can unlock. Once you complete Guillotina's first boss fight, take the Throbbing Gristle to the Wall of Flesh. Then, take the Putrid Leach from Guillotina's second boss fight to the Throbbing Artery in The Boneyard. Complete the third boss fight, and equip her head to one of your cats. Then, go to the altar in the Throbbing Domain and sacrifice the cat (that has Guillotina's head equipped).

Desert

Finish a run in The Boneyard and in The Caves.

The Bunker

Finish a run in The Desert.

The Core

Finish a run in The Bunker.

The Crater

Finish a run in The Desert.

The Moon

Finish a run in The Crater.

The Rift

This is the second secret stage in the game. You'll meet Pyrophina and Zaratan once you've cleared runs on The Moon and The Core. Defeat both of them and take the Burning orb from Pyrophina. Feed it to the Man on the Moon by making a cat stand in front of him while holding the item. Next, charge Zaratana's Shard by killing 20 enemies with the item equipped. Take the shard to the Coven on the Core and insta-kilit with the Shard. Now, both Pyrophina and Zaratana will return to your house.
Once their fight is over, you'll get a collar. If you get Pyrophina's collar, take it to the obelisk at the end of The Moon. If you get Zaratana's collar, take it to the Core obelisk.

The Lab

Finish a run in The Core and The Moon.

Ice Age

Finish a run in The Lab.

The Future

Finish a run in The Lab.

The Jurassic

Finish a run in The Ice Age.

The End

Finish a run in The Future.

The Infinite

Finish a run in The Jurassic and The End.

The post All Acts and Areas in Mewgenics and how to unlock them appeared first on Destructoid.

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